Route to three-dimensional fragments using diversity-oriented synthesis

作者: J. A. Wilson , P. A. Clemons , D. W. Young , A. W. Hung , A. Ramek

DOI: 10.1073/PNAS.1015271108

关键词:

摘要: … Diversity-oriented synthesis (DOS) aims to efficiently generate a set of molecules diverse in skeletal and stereochemical properties. Molecules derived from DOS have also displayed …

参考文章(39)
David J. Payne, Michael N. Gwynn, David J. Holmes, David L. Pompliano, Drugs for bad bugs: confronting the challenges of antibacterial discovery Nature Reviews Drug Discovery. ,vol. 6, pp. 29- 40 ,(2007) , 10.1038/NRD2201
Anthony G Coyne, Duncan E Scott, Chris Abell, Drugging challenging targets using fragment-based approaches. Current Opinion in Chemical Biology. ,vol. 14, pp. 299- 307 ,(2010) , 10.1016/J.CBPA.2010.02.010
Stuart L. Schreiber, Organic chemistry: Molecular diversity by design. Nature. ,vol. 457, pp. 153- 154 ,(2009) , 10.1038/457153A
Soon Hyeok Hong, Michael W. Day, Robert H. Grubbs, Decomposition of a Key Intermediate in Ruthenium-Catalyzed Olefin Metathesis Reactions Journal of the American Chemical Society. ,vol. 126, pp. 7414- 7415 ,(2004) , 10.1021/JA0488380
Miles Congreve, Robin Carr, Chris Murray, Harren Jhoti, A 'rule of three' for fragment-based lead discovery? Drug Discovery Today. ,vol. 8, pp. 876- 877 ,(2003) , 10.1016/S1359-6446(03)02831-9
Thomas E. Nielsen, Stuart L. Schreiber, Towards the Optimal Screening Collection: A Synthesis Strategy Angewandte Chemie. ,vol. 47, pp. 48- 56 ,(2008) , 10.1002/ANIE.200703073
Alessio Ciulli, Chris Abell, Fragment-based approaches to enzyme inhibition. Current Opinion in Biotechnology. ,vol. 18, pp. 489- 496 ,(2007) , 10.1016/J.COPBIO.2007.09.003
Miles Congreve, Gianni Chessari, Dominic Tisi, Andrew J. Woodhead, Recent developments in fragment-based drug discovery. Journal of Medicinal Chemistry. ,vol. 51, pp. 3661- 3680 ,(2008) , 10.1021/JM8000373
Brian R. McNaughton, Kevin M. Bucholtz, Ana Camaaño-Moure, Benjamin L. Miller, Self-selection in olefin cross-metathesis: the effect of remote functionality. Organic Letters. ,vol. 7, pp. 733- 736 ,(2005) , 10.1021/OL047361U
David A. Spiegel, Frank C. Schroeder, Jeremy R. Duvall, Stuart L. Schreiber, An oligomer-based approach to skeletal diversity in small-molecule synthesis. Journal of the American Chemical Society. ,vol. 128, pp. 14766- 14767 ,(2006) , 10.1021/JA065724A