Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

作者: Christopher G Willett , Yves Boucher , Emmanuelle di Tomaso , Dan G Duda , Lance L Munn

DOI: 10.1038/NM988

关键词:

摘要: The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single infusion of the VEGF-specific …

参考文章(15)
Peter Carmeliet, Rakesh K. Jain, Angiogenesis in cancer and other diseases Nature. ,vol. 407, pp. 249- 257 ,(2000) , 10.1038/35025220
Alessandra Burlini, Silvia Monestiroli, Francesco Bertolini, Patrizia Mancuso, Giancarlo Pruneri, Giovanni Martinelli, Chiara Dell’Agnola, Alberto Gobbi, Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Research. ,vol. 61, pp. 4341- 4344 ,(2001)
Patrizia Mancuso, Alessandra Burlini, Giancarlo Pruneri, Aron Goldhirsch, Giovanni Martinelli, Francesco Bertolini, Resting and activated endothelial cells are increased in the peripheral blood of cancer patients Blood. ,vol. 97, pp. 3658- 3661 ,(2001) , 10.1182/BLOOD.V97.11.3658
Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter, None, The biology of VEGF and its receptors. Nature Medicine. ,vol. 9, pp. 669- 676 ,(2003) , 10.1038/NM0603-669
Shahin Rafii, David Lyden, Robert Benezra, Koichi Hattori, Beate Heissig, Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nature Reviews Cancer. ,vol. 2, pp. 826- 835 ,(2002) , 10.1038/NRC925
James C. Yang, Leah Haworth, Richard M. Sherry, Patrick Hwu, Douglas J. Schwartzentruber, Suzanne L. Topalian, Seth M. Steinberg, Helen X. Chen, Steven A. Rosenberg, A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer The New England Journal of Medicine. ,vol. 349, pp. 427- 434 ,(2003) , 10.1056/NEJMOA021491
Rakesh K Jain, Molecular regulation of vessel maturation. Nature Medicine. ,vol. 9, pp. 685- 693 ,(2003) , 10.1038/NM0603-685
Robert Kerbel, Judah Folkman, Clinical translation of angiogenesis inhibitors Nature Reviews Cancer. ,vol. 2, pp. 727- 739 ,(2002) , 10.1038/NRC905