Preoperative Mobilization of Circulating Dendritic Cells by Flt3 Ligand Administration to Patients With Metastatic Colon Cancer
作者： Michael A. Morse , Smita Nair , Monica Fernandez-Casal , Yuping Deng , Michelle St Peter
DOI: 10.1200/JCO.2000.18.23.3883
关键词:
摘要: PURPOSE: To evaluate preoperative dendritic cell (DC) mobilization and tumor infiltration after administration of Flt3 ligand (Flt3L) to patients with metastatic colon cancer. PATIENTS AND METHODS: Twelve cancer the liver or lung received Flt3L (20 μg/kg/d subcutaneously for 14 days one three cycles at monthly intervals) before attempted metastasectomy. The number phenotype DCs mobilized into peripheral-blood mononuclear cells (PBMCs) were evaluated by flow cytometry. After surgical resection, tissue was DC infiltration. In vivo immune responses recall antigens measured. RESULTS: administration, on average, total leukocytes in peripheral blood increased from 5.9 ± 1.0 × 103/mm3 11.2 3.8 (mean SD, P = .0001). percentage CD11c+CD14− PBMCs 2.4% 1.8% 8.8% 4.7% (P .004). Delayed-type hypersensitivity (DTH) (Candi...
sci-hub.se 参考文章(19)
Dmitry I. Gabrilovich, Michael R. Shurin, Michael T. Lotze, Joyce E. Ohm, David P. Carbone, Clemens Esche, Effect of Vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation In Vivo Journal of Immunology. ,vol. 163, pp. 3260- 3268 ,(1999)
Adrian A. Maung, Nikola L. Vujanovic, Raymond J. Steptoe, Angus W. Thomson, Samuel G. Shaw, Expansion of Functional NK Cells in Multiple Tissue Compartments of Mice Treated with Flt3-Ligand: Implications for Anti-Cancer and Anti-Viral Therapy Journal of Immunology. ,vol. 161, pp. 2817- 2824 ,(1998)
Hal E. Broxmeyer, Christie M. Traycoff, Stewart Lyman, George Sledge, Yi Fan, Kenneth Cornetta, Keyue Chen, Stephen Braun, Jay Gaddy, Eric A. Wiebke, Antitumor Activity and Immunotherapeutic Properties of Flt3-Ligand in a Murine Breast Cancer Model Cancer Research. ,vol. 57, pp. 3511- 3516 ,(1997)
Michael R. Shurin, Michael T. Lotze, Vladimir M. Subbotin, Jean-Marie Péron, Clemens Esche, Charles Maliszewski, FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells Journal of Immunology. ,vol. 161, pp. 6164- 6170 ,(1998)
Michael R. Shurin, Michael T. Lotze, Vladimir M. Subbotin, Clemens Esche, Charles Maliszewski, FLT3 ligand administration inhibits tumor growth in murine melanoma and lymphoma Cancer Research. ,vol. 58, pp. 380- 383 ,(1998)
Christel Buelens, Valérie Verhasselt, Donat De Groote, Kris Thielemans, Michel Goldman, Fabienne Willems, Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor European Journal of Immunology. ,vol. 27, pp. 756- 762 ,(1997) , 10.1002/EJI.1830270326
David H. Lynch, Alice Andreasen, Eugene Maraskovsky, James Whitmore, Robert E. Miller, Joann C.L. Schuh, Flt3 ligand induces tumor regression and antitumor immune responses in vivo Nature Medicine. ,vol. 3, pp. 625- 631 ,(1997) , 10.1038/NM0697-625
Michael R. Shurin, Pratik P. Pandharipande, Tatiana D. Zorina, Catherine Haluszczak, Vladimir M. Subbotin, Oriana Hunter, Anne Brumfield, Walter J. Storkus, Eugene Maraskovsky, Michael T. Lotze, FLT3 Ligand Induces the Generation of Functionally Active Dendritic Cells in Mice Cellular Immunology. ,vol. 179, pp. 174- 184 ,(1997) , 10.1006/CIMM.1997.1152
B. Pulendran, J. L. Smith, G. Caspary, K. Brasel, D. Pettit, E. Maraskovsky, C. R. Maliszewski, Distinct dendritic cell subsets differentially regulate the class of immune response in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 1036- 1041 ,(1999) , 10.1073/PNAS.96.3.1036
H. J. McKenna, Generating a T cell tumor-specific immune response in vivo: can flt3-ligand-generated dendritic cells tip the balance? Cancer Immunology, Immunotherapy. ,vol. 48, pp. 281- 286 ,(1999) , 10.1007/S002620050576