Adaptive circadian rhythm estimator and its application to locomotor activity

摘要: Disruption of the circadian rhythm is detrimental to human well being, with consequences ranging from lower productivity, sleep disorder, more serious health problems. Accurate estimation critical assessment and treatment disruption. Circadian estimate also essential for light-based entrainment. Direct measurements markers such as dim light melatonin onset are inconvenient acquired at best low rate. Wearable continuous actigraph body temperature convenient but masked by many other factors. In this paper, we present a new scheme based on adaptive notch filter (ANF) which commonly used in signal processing. The ANF designed track gain phase single sinusoid noisy data. We extend classic multiple harmonics non-zero bias needed tracking. modified tested rat Drosophila locomotor activity data extract argument. results compared linear regression gliding cosinor. ability generate opens up tantalizing possibility personalized estimator therapy.