摘要: Narcolepsy is a severe, incurable, neurological disorder that treated by pharmacological management of its symptoms. The main symptoms are excessive daytime sleepiness (EDS) and cataplexy, although addition may require treatment include sleep paralysis, hypnagogic hallucinations, disturbed nocturnal sleep. Sodium oxybate modafinil/armodafinil the first-line treatments for EDS, sodium cataplexy. treats all narcolepsy, whereas modafinil effective EDS only. Alternative medications methylphenidate or amphetamines such as dextroamphetamine, lisdexamfetamine, methamphetamine, combination amphetamine salts. Non-FDA approved cataplexy norepinephrine reuptake inhibitors venlafaxine atomoxetine. Combination therapy can be more modafinil/armodafinil. Medication narcolepsy generally well tolerated usually required life-long does not eliminate narcolepsy.
springer.com
elsevier.com
sci-hub.se 参考文章(51)
Jonathan R. L. Schwartz, Michael T. Nelson, Elliott R. Schwartz, Rod J. Hughes, Effects of modafinil on wakefulness and executive function in patients with narcolepsy experiencing late-day sleepiness. Clinical Neuropharmacology. ,vol. 27, pp. 74- 79 ,(2004) , 10.1097/00002826-200403000-00005
J. Frey, C. Darbonne, Fluoxetine suppresses human cataplexy: A pilot study Neurology. ,vol. 44, pp. 707- 707 ,(1994) , 10.1212/WNL.44.4.707
S. Nightingale, J.C. Orgill, I.O. Ebrahim, S.F. de Lacy, S. Agrawal, A.J. Williams, The association between narcolepsy and REM behavior disorder (RBD). Sleep Medicine. ,vol. 6, pp. 253- 258 ,(2005) , 10.1016/J.SLEEP.2004.11.007
Benedetto Vitiello, Understanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function. Child and Adolescent Psychiatric Clinics of North America. ,vol. 17, pp. 459- 474 ,(2008) , 10.1016/J.CHC.2007.11.010
Hashir Majid, Max Hirshkowitz, Therapeutics of Narcolepsy Sleep Medicine Clinics. ,vol. 5, pp. 659- 673 ,(2010) , 10.1016/J.JSMC.2010.08.007
Smaranda Leu-Semenescu, Valerie Cochen De Cock, Valerie Dauriac Le Masson, Rachel Debs, Sophie Lavault, Emmanuel Roze, Marie Vidailhet, Isabelle Arnulf, Hallucinations in narcolepsy with and without cataplexy: Contrasts with Parkinson’s disease Sleep Medicine. ,vol. 12, pp. 497- 504 ,(2011) , 10.1016/J.SLEEP.2011.03.006
Fabio Pizza, Christian Franceschini, Hanna Peltola, Stefano Vandi, Elena Finotti, Francesca Ingravallo, Lino Nobili, Oliviero Bruni, Ling Lin, Mark J. Edwards, Markku Partinen, Yves Dauvilliers, Emmanuel Mignot, Kailash P. Bhatia, Giuseppe Plazzi, Clinical and polysomnographic course of childhood narcolepsy with cataplexy Brain. ,vol. 136, pp. 3787- 3795 ,(2013) , 10.1093/BRAIN/AWT277
Deborah L. Zvosec, Stephen W. Smith, Trinka Porrata, A. Quinn Strobl, Jo Ellen Dyer, Case series of 226 γ-hydroxybutyrate–associated deaths: lethal toxicity and trauma The American Journal of Emergency Medicine. ,vol. 29, pp. 319- 332 ,(2011) , 10.1016/J.AJEM.2009.11.008
Lawrence P. Carter, Christine Acebo, Ann Kim, Patients' Journeys to a Narcolepsy Diagnosis: A Physician Survey and Retrospective Chart Review Postgraduate Medicine. ,vol. 126, pp. 216- 224 ,(2014) , 10.3810/PGM.2014.05.2769
Yves Dauvilliers, Claudio Bassetti, Gert Jan Lammers, Isabelle Arnulf, Geert Mayer, Andrea Rodenbeck, Philippe Lehert, Claire-Li Ding, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial The Lancet Neurology. ,vol. 12, pp. 1068- 1075 ,(2013) , 10.1016/S1474-4422(13)70225-4