Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins.
作者： Vashendriya V.V. Hira , Jill R. Wormer , Hala Kakar , Barbara Breznik , Britt van der Swaan
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摘要: In glioblastoma, a fraction of malignant cells consists therapy-resistant glioblastoma stem (GSCs) residing in protective niches that recapitulate hematopoietic cell (HSC) bone marrow. We have previously shown HSC niche proteins stromal cell-derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin (OPN), and cathepsin K (CatK) are expressed hypoxic GSC around arterioles five human samples. niches, HSCs retained by binding SDF-1α OPN to their receptors CXCR4 CD44, respectively. Protease CatK cleaves release out niches. The aim the present study was reproduce immunohistochemical localization these markers 16 samples with addition three novel markers. Furthermore, we assessed blood vessels associated total, found seven containing CD133-positive nestin-positive GSCs as single-cell layer exclusively tunica adventitia 2% CD31-positive SMA-positive not capillaries venules. Niches SDF-1α, CXCR4, CatK, OPN, hypoxia-inducible factor-1α, vascular endothelial growth factor. conclusion, show express marrow proteins.
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