In vitro food-drug interaction study: Which milk component has a decreasing effect on the bioavailability of ciprofloxacin?

摘要: The purpose of the present work was developing an in vitro dissolution test to highlight possible molecular background causing ciprofloxacin (CPFX)-milk interaction. CPFX from film-coated tablets (Ciprinol) 500mg) examined at different pH values, simulating certain parts gastrointestinal tract, presence water, low-fat milk, casein- or calcium enriched water. In order determine amount dissolved CPFX, solid phase extraction sample preparation followed by high performance liquid chromatography coupled with mass spectrometry applied. Comparing efficiency values various media, it can be concluded, that casein has a more pronounced effect on absorbable antibiotic each value studied, than calcium. case concomitant intake tablet and milk other dairy products not only complexation calcium, but also adsorption surface proteins decreases CPFX.