Aging of skeletal muscle fibers.

摘要: Aging has become an important topic for scientific research because life expectancy and the number of men women in older age groups have increased dramatically last century. This is true most countries world including Republic Korea United States. From a rehabilitation perspective, associated issue progressive decline functional capacity independence. Sarcopenia partly responsible this decline. Many changes underlying loss muscle mass force-generating skeletal can be understood at cellular molecular levels. Muscle size architecture are both altered with advanced adult age. Further, myofibers include impairments several physiological domains fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, repair regeneration. A thorough understanding these alterations lead to design improved preventative rehabilitative interventions, such as personalized exercise training programs.