Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases

摘要: The F-actin cytoskeleton is a fundamental component of all eukaryotic cells. It provides force and stability plays an integral role in diverse array cellular processes. spatiotemporal regulation dynamics essential for proper biological output. basic molecular machinery underlying the assembly disassembly filamentous actin conserved Additionally, protein tyrosine kinases, found only multicellular eukaryotes, provide links between extracellular signals F-actin-dependent Among c-Abl its relative Arg are unique binding directly to F-actin. Recent results have demonstrated membrane ruffling, cell spreading, migration, neurite extension response growth factor matrix signals. appears regulate polymers into different structures, depending on signal. Interestingly, contains nuclear import export signals, inhibits differentiation promotes apoptosis genotoxic stress. modular structure nuclear-cytoplasmic shuttling suggest that it integrates multiple coordinate with decision differentiate or die.