Early Postoperative Intraperitoneal Chemotherapy as an Adjuvant Therapy to Surgery for Peritoneal Carcinomatosis from Gastrointestinal Cancer: Pharmacological Studies

摘要: Gastrointestinal malignancy may spread to peritoneal surfaces in the absence of lymphatic or hematogenous metastases. To treat carcinomatosis, a uniformly lethal disease process, extensive cytoreductive surgery and i.p. chemotherapy were combined. Early postoperative was instilled first few days after surgical procedure an attempt anatomic sites that would be sealed off by adhesions. Mitomycin C given on day at two doses, 10 12 mg/m2. 5-Fluorouracil 2-5 15 20 mg/kg, respectively. Median area under curve ratio i.p./i.v. 117 for 5-fluorouracil 21.6 mitomycin C. Elevated intraportal levels drug observed but not The marked pharmacokinetic advantage suggests this treatment strategy should considered clinical trial patients risk progression carcinomatosis.