Lack of an effect of vitamin E on lifespan of mice.

作者: Alexander A. Morley , Kevin J. Trainor

DOI: 10.1023/A:1011589218219

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摘要: It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing the action oxidising free radicals. This possibility would predict administration anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups mice were exposed throughout life, time conception until death, 20, 40 and 400 mg/kg vitamin E in diet. No effect lifespan was observed median lifespans three 804, 830 801 days, respectively. The design study also enabled an parental age female progeny be sought, no detected.

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