Myeloperoxidase: the yin and yang in tumour progression.

摘要: Myeloperoxidase (MPO) is a heme- containing enzyme abundantly expressed in neutrophils. It catalyzes the reaction between chloride and hydrogen peroxide to generate potent oxidant, hypochlorous acid (HOCl). plays an important role innate immune defense mechanism. However, excessive generation of MPO-derived oxidants has been linked tissue damage initiation progression diseases such as cancer which arise from chronic inflammation. The oxidant activity MPO believed promote metabolism chemical carcinogens, cause DNA compromise repair process. also considered mediators gastric ulcers caused by Helicobacter pylori (H. pylori) through its ability catalyze reactive oxidants. A G-463 polymorphism located promoter gene transcription. Moreover produced neutrophilic have potential interact with tumour cells contribute their metastasis. There considerable interest screening plant extracts compounds isolated them for use HOCl scavengers. This review will discuss provide overview part metastasis ulcer.