An iGlu Receptor Antagonist and Its Simultaneous Use with an Anticancer Drug for Cancer Therapy
作者： Si Yu Tan , Chung Yen Ang , Zhong Luo , Peizhou Li , Kim Truc Nguyen
关键词:
摘要: Glutamate receptor antagonists have been known to play a crucial role in the treatment of many neuronal diseases. Recently, these also shown therapeutic effects cancer. In this study, an ionotropic glutamate (iGlu) antagonist, 4-hydroxyphenylacetyl spermine (L1), was used concurrently with common anticancer drug, doxorubicin (Dox), for simultaneous cancer therapy. Mesoporous silica nanoparticles (MSNPs) were employed as delivery vehicle both L1 and Dox by conjugating iGlu antagonist on surface encapsulating within mesopores. then trapped mesopores functionalizing redox-cleavable capping group MSNP surface, it could be released upon exposure reductive glutathione. vitro studies B16F10 NIH3T3 cell lines revealed that exhibited well targeting effects. addition, use proved synergistic The present work demonstrated feasibility employing system deliver neuroprotective drug efficient treatment.
sci-hub.se 参考文章(59)
Jerry W. Lin, William Ju, Kelly Foster, Sang Hyoung Lee, Gholamreza Ahmadian, Michael Wyszynski, Yu Tian Wang, Morgan Sheng, Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization Nature Neuroscience. ,vol. 3, pp. 1282- 1290 ,(2000) , 10.1038/81814
Takahiro Takano, Jane H.-C. Lin, Gregory Arcuino, Qun Gao, Jay Yang, Maiken Nedergaard, Glutamate release promotes growth of malignant gliomas. Nature Medicine. ,vol. 7, pp. 1010- 1015 ,(2001) , 10.1038/NM0901-1010
Takahisa Hanada, Yutaka Hashizume, Naoki Tokuhara, Osamu Takenaka, Naohiro Kohmura, Aichi Ogasawara, Shinji Hatakeyama, Makoto Ohgoh, Masataka Ueno, Yukio Nishizawa, Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. ,vol. 52, pp. 1331- 1340 ,(2011) , 10.1111/J.1528-1167.2011.03109.X
G M Gilad, V H Gilad, Novel Polyamine Derivatives as Neuroprotective Agents Journal of Pharmacology and Experimental Therapeutics. ,vol. 291, pp. 39- 43 ,(1999)
Seong Huh, Jerzy W. Wiench, Brian G. Trewyn, Seahn Song, Marek Pruski, Victor S.-Y. Lin, Tuning of particle morphology and pore properties in mesoporous silicas with multiple organic functional groups. Chemical Communications. pp. 2364- 2365 ,(2003) , 10.1039/B306255D
Ji Eun Lee, Nohyun Lee, Hyoungsu Kim, Jaeyun Kim, Seung Hong Choi, Jeong Hyun Kim, Taeho Kim, In Chan Song, Seung Pyo Park, Woo Kyung Moon, Taeghwan Hyeon, None, Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery Journal of the American Chemical Society. ,vol. 132, pp. 552- 557 ,(2010) , 10.1021/JA905793Q
S Nakanishi, Molecular diversity of glutamate receptors and implications for brain function. Science. ,vol. 258, pp. 597- 603 ,(1992) , 10.1126/SCIENCE.1329206
Márcia Renata Mortari, Alexandra Olimpio Siqueira Cunha, Luzitano Brandão Ferreira, Wagner Ferreira dos Santos, Neurotoxins from invertebrates as anticonvulsants: From basic research to therapeutic application ☆ Pharmacology & Therapeutics. ,vol. 114, pp. 171- 183 ,(2007) , 10.1016/J.PHARMTHERA.2007.01.009
Paulo S. Pinheiro, Christophe Mulle, Presynaptic glutamate receptors: physiological functions and mechanisms of action Nature Reviews Neuroscience. ,vol. 9, pp. 423- 436 ,(2008) , 10.1038/NRN2379
Andrzej Stepulak, Radoslaw Rola, Krzysztof Polberg, Chrysanthy Ikonomidou, Glutamate and its receptors in cancer Journal of Neural Transmission. ,vol. 121, pp. 933- 944 ,(2014) , 10.1007/S00702-014-1182-6