Genetic Control of Susceptibility of Rats to Gastric Carcinoma
作者： Hiroko Ohgaki , Norio Matsukura , Takashi Kawachi , Kazuhide Morino , Takashi Sugimura
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摘要: Abstract Genetic control of the induction gastric tumors by N -methyl- ′-nitro- -nitrosoguanidine (MNNG) was studied in susceptible ACI rats, resistant Buffalo and their F 1 2 offspring. Both sexes all strains, initially 7 to 9 weeks old, were given MNNG at a concentration 83 µg/ml drinking water for 32 sacrificed experimental Week 72. The incidence adenocarcinoma rats 80% males 47% females; 18% 0% females. hybrids showed same resistance as did rats; 17% 8% These results suggest that is dominant characteristic. generation 36% 14% females, which close 3:1 ratio expected from segregation single gene. In strains hybrids, more than females carcinoma MNNG. Intestinal observed mainly duodenum jejunum both incidences follows: ACI: males, 67% 42%; Buffalo: 12% 18%; : 15%; 15% 19%. Thus, there seems be common genetic basis intestinal carcinogenesis
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