Splenectomy in Lymphoproliferative Disorders: a Report on 70 Cases and Review of the Literature

摘要: Between February, 1970 and September, 1991, we performed splenectomies on 70 patients with chronic lymphoproliferative disorders including primary leukemias: 19 B-cell lymphocytic leukemia, 1 prolymphocytic 22 hairy cell leukemias, 4 large granular T-cell non-Hodgkin's lymphomas (NHL): 10 splenic villous lymphocytes, follicular lymphomas, 5 mantle 3 lymphoplasmacytic NHL. The indications for surgery in this series were therapy-resistant disease (40%) therapeutic splenectomy (38%). Postsplenectomy, 70% of had a complete hematological response, 23% partial 7% nonresponsive. Median treatment-free survival correlated the hematologic response postsplenectomy underlying diagnosis. Better survivals seen lesser degrees anemia thrombocytopenia. Overall, improvements more pronounced than disorders. Indications further therapy, postoperative morbidity mortality, times are discussed along review literature. These findings advocate continuing role symptomatic lymphoid malignancies running splenomegaly hypersplenism.