Envolvimento dos receptores 5-HT2 da amígdala nos níveis de ansiedade induzidos pela exposição de ratos ao labirinto em cruz elevado

摘要: The effect of microinjections the 5-HT2A/2C receptor antagonist RP62203 (1,0; 2,5; 5,0 mg) in amygdala was investigated on traditional and ethological (scanning, risk-assessment, explorations extremities) anxiety measures rats elevated plus-maze test. dose mg increased percentages entries time spent open arms, without altering number closed arm entries. Scanning, risk-assessment end exploration were also changed by treatment, there being an increase scanning (2,5 a reduction mg). extremities mg. This behavioral profile suggests anxiolytic RP 62203. participation receptors regulation those effects is discussed.