Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse.

摘要: Spinal cord injury (SCI) in mammals leads to a robust inflammatory response followed by the formation of glial and connective tissue scar that comprises barrier axonal regeneration. The inbred MRL/MpJ mouse strain exhibits reduced inflammation after peripheral shows true regeneration without following an ear punch wound. We hypothesized SCI, unique genetic wound healing traits this would result formation, increased growth, improved functional recovery. Adult C57BL/6J mice were subjected mid-thoracic spinal contusion distribution axon profiles selected cellular extracellular matrix components was compared at 1, 2, 4 6 weeks post-injury. Recovery hind-limb locomotor function assessed over same time period. exhibited growth within lesion, beginning This accompanied macrophage staining post-injury, decreased chondroitin sulfate proteoglycan 1-2 laminin throughout lesion 2-6 Paradoxically, extent recovery impaired mice. Close examination chronic site revealed evidence ongoing degeneration both surrounding site. Thus, regenerative contribute evolution environment supports enhanced SCI. However, occurs expense meaningful