Lower‐dose 13C‐urea breath test to detect Helicobacter pylori infection—comparison between infrared spectrometer and mass spectrometry analysis

摘要: Background: The expense of the 13C-urea breath test (UBT) to detect Helicobacter pylori infection is mainly due cost and analysis using isotope ratio mass spectrometry (IRMS). Aim: To whether a UBT, lower dose urea lower-priced isotope-selective nondispersive infrared (INIS), can preserve diagnostic efficacy in clinical practice. Methods: A total 177 dyspeptic patients received endoscopy for H. culture histology. All them UBT which duplicate baseline, 10 min, 15 min samples after ingestion 50 mg were collected analyse excess 13CO2/12CO2 (ECR) by IRMS (ABCA, Europa Scientific, UK) INIS (UBiT-IR200, Photal Otsuka Electronics, Japan), respectively. Results: Of patients, 84 infected 93 uninfected with pylori. A close correlation ECR was found between (r=0.9829 at 10 min; r=0.9918 15 min, P < 0.0001). Analysing 15-min samples, both achieved same sensitivity (96.4%) specificity (98.9%). Conclusions: INIS as effective use 13C-urea. This provide an economic low