The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients.

摘要: Background : Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, pre-identification of transplant patients at increased risk for non-melanoma remains difficult. Objective To investigate Hp polymorphism as a marker identification subset with an susceptibility to develop SCC/Bowen's disease. Methods Haptoglobin phenotyping was performed haemoglobin-supplemented starch gel electrophoresis in 300 kidney patients. High-performance permeation chromatography used case low serum haptoglobin concentration. Results Cox regression analysis (adjusted age, gender and Mediterranean origin) showed significant association 1-1 phenotype higher disease (P = 0.035) multiple primary SCCs 0.002). No difference between phenotypes found development Bowen's first 10 years following renal However, follow-up >10 years, occurrence SCC reported 0.002 P 0.001 respectively). Conclusions This study shows (multiple) phenotype. finding points role important predictor identifying need preventive measures agreement decreased anti-inflammatory capacity this