HIV-1 Can Persist in Aged Memory CD4+ T Lymphocytes With Minimal Signs of Evolution After 8.3 Years of Effective Highly Active Antiretroviral Therapy
作者： Hans S L M Nottet , Sabine J van Dijk , Ewout B Fanoy , Irma W Goedegebuure , Dorien de Jong
DOI: 10.1097/QAI.0B013E318197EB04
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摘要: Background:Patients on long-term highly active antiretroviral therapy (HAART) were studied to determine persistence, drug resistance development, and evolution of HIV-1 proviral DNA.Methods:Peripheral blood mononuclear cells obtained by large volume drawn (500 mL) from 8 clinically succes
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