Decay of HIV Type 1 DNA and Development of Drug-Resistant Mutants in Patients with Primary HIV Type 1 Infection Receiving Highly Active Antiretroviral Therapy

摘要: The present study was aimed at describing the effect of highly active antiretroviral therapy (HAART) in 10 patients with primary HIV infection (PHI). Clearance rates RNA and DNA peripheral blood as well preexistence emergence drug-resistant strains were determined over 52 weeks treatment. data indicate that HAART is able to induce a suppression plasma viral load together significant decrease, but not suppression, mononuclear cell-associated proviral PHI subjects. Analysis revealed three patients, showing complete virologic response, developed mutations pol gene, thus suggesting persistent residual virus replication exists despite sustained viremia.