Regulation of antigen receptor signal transduction by protein tyrosine kinases
作者： Andrew C Chan , Andrey S Shaw
DOI: 10.1016/S0952-7915(96)80130-0
关键词:
摘要: The past two years have seen further clarification of the early events occurring in antigen receptor signal transduction that are mediated by immunoreceptor tyrosine-based activation motif (ITAM). ITAM was shown to be a specific binding site for ZAP-70/Syk protein tyrosine kinases and structure this complex solved. In addition, possible mechanisms functions these were reported. Lastly, genetic studies established critical importance antigen-receptor signaling lymphocyte development.
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