Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis
作者： Rebecca Russ , Frank J. Slack
DOI: 10.1155/2012/791234
关键词:
摘要: Dysregulation of microRNAs (miRNAs), particularly their downregulation, has been widely shown to be associated with the development lung cancer. Downregulation miRNAs leads overactivation oncogene targets, while upregulation some inhibition important tumor suppressors. Research implicated cigarette smoke in miRNA dysregulation, leading carcinogenesis. Cigarette may lead genetic or epigenetic damage miRNAs, many which map fragile sites and contain single nucleotide polymorphisms. also cause dysregulation by affecting regulatory mechanisms controlling expression. Researchers have a correlation between smoke-exposure-induced age. Furthermore, seems intensity duration exposure cessation. Longer at threshold level is needed for irreversibility changes Better understanding allow improved biomonitoring treatment regimens
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