The taurine transporter gene and its role in renal development.

摘要: This paper examines a unique hypothesis regarding an important role for taurine in renal development. Taurine-deficient neonatal kittens show developmental abnormalities, one of several lines support this speculation. Adaptive regulation the transporter gene is critical mammalian species because maintenance adequate tissue levels essential to normal development retina and central nervous system. Observations remarkable phenotypic similarity that exists between children with deletion bands p25-pter chromosome 3 taurine-deficient kits led us hypothesize (TauT) might contribute some features 3p-syndrome. Further, down-regulated by tumor suppressor p53, up-regulated Wilms (WT-1) early growth response-1 (EGR-1) genes. It has been demonstrated using WT-1 knockout mice In contrast, transgenic overexpressing p53 have defects, including hypoplasia similar observed kitten. reviews evidence altered expression may result reduced intracellular content, which turn lead abnormal cell volume regulation, death and, ultimately, defective