Imaging infections with antibodies. A quantitative autoradiographic analysis.

摘要: Radiolabeled IgG has recently been demonstrated to effectively image infections. A potential but unproven mechanism for this localization is the specific binding of Fc receptors on surface inflammatory cells in In an animal model soft tissue infection, quantitative autoradiography was used measure 125I-labeled and albumin tissues with a spatial resolution sufficient associate these proteins cellular morphology. Gamma camera images at 24 h localized infection target-to-background ratios 2.2 ± 0.5 2.3 1.0 (mean SD). Using 1 post-injection, significantly higher concentrations were found infected thighs 2–4% initial plasma (CPo) as compared 0.2–0.3% CPo noninfected (P < 0.05); (7–8% CPo) thighs. not cell associated primarily within edematous interstital spaces infection.