Congenital diaphragmatic hernia and exercise capacity, a longitudinal evaluation

摘要: Objective: Children with congenital diaphragmatic hernia (CDH) suffer from long-term pulmonary morbidity. Longitudinal data of exercise capacity in these children are lacking. We hypothesized that would be impaired with CDH and deteriorates over time. evaluated its determinants in CDH patients longitudinally until 12 years age. Design: Prospective longitudinal follow-up study tertiary university hospital. Patients: One hundred fourteen born between 1999 2012. Methods: Exercise was using the Bruce treadmill-protocol at the ages 5, 8, years. Primary outcome parameter standard deviation score (SDS) maximal endurance Data were analyzed by linear mixed models. Results:A total 107 (30 treated extracorporeal membrane oxygenation [ECMO]) performed 191 reliable tests. At ages years, mean (95%CI) SDS time −0.44 (−0.65 to −0.24); −1.01 (−1.23 −0.78); −1.10 (−1.40 −0.80), respectively, all less than zero (P < 0.001). declined significantly irrespective ECMO-treatment (5-12 years: non-ECMO P = 0.015; ECMO P 0.006). Duration initial hospital stay diffusion capacity corrected for alveolar volume associated 0.001 and P 0.039). Conclusions: In 5 of age, ECMO-treatment. may benefit long-term assessments timely intervention.