The Intestinal Trophic Response to Enteral Food Is Reduced in Parenterally Fed Preterm Pigs and Is Associated with More Nitrergic Neurons

摘要: In term neonates, total parenteral nutrition (TPN) induces mucosal atrophy, whereas the first intake of milk is followed by intestinal growth. This may be explained in part an NO-mediated increased blood flow. We hypothesized that immature gut has altered response to TPN and enteral nutrition. Expt. 1, preterm caesarean-delivered pigs were administered elemental nutrients for 3 d, infused parenterally (TPN, n = 7) or enterally (TENT, 7). 2, fed sow's colostrum, cow's infant formula 2 d after a 3-d period (TPN-SOW, TPN-COW, TPN-FORM, 8-11). Intestinal morphology number enteric neurons containing nitric oxide synthase-1 (NOS-1) quantified. Both TENT groups had increases mass, circumference, volume, surface density, relative values at birth (+30-50%, P < 0.05). magnitudes trophic responses feeding similar those but also associated with nitrergic myenteric some damage, most frequently observed group. conclude 1) short does not induce atrophy pigs, luminally do mimic seen diets, 2) modest, diet-dependent related actions population NOS-1 neurons.