Adenovirus-mediated In Vivo Gene Therapy

摘要: Adenoviruses are widespread in nature since they have been found many mammalian and avian species. All members of the adenovirus family similar chemical physical properties, but can be distinguished by their individual type-specific antigens. In man, 47 distinct serotypes (Ad1 to Ad47) that form six groups (A F) isolated date, most them during decade following discovery Rowe (1953). Host specificity seems very stringent inasmuch as no spread from one host species another has ever reported. An abortive growth cycle usually results after infection cells with virus Clinical illness associated depends on serotype, is mild rarely life-threatening. The primary target for cytopathology epithelial cell. Productive infections human adenoviruses take place gastrointestinal, respiratory, or ocular cells, resulting pathological alterations mediated direct tissue damage. For example, some (Ad 3, 20) “swimming pool conjunctivitis” gastroenteritis (Ad40), while Ad5 responsible respiratory illnesses. near-terminally differentiated quiescent upper tract lining natural which replicates. From sites viral progeny then enter bloodstream other body tissues.