Optimization of anesthesia antiemetic measures versus combination therapy using dexamethasone or ondansetron for the prevention of postoperative nausea and vomiting

摘要: More than half of the patients undergoing laparoscopic cholecystectomy experience postoperative nausea and vomiting (PONV). This condition is related to surgical, anesthetic, patient factors. Volatile anesthetics, nitrous oxide, opioids are known anesthetic risk factors for PONV, thus preventive measures justified. Propofol-based total intravenous anesthesia (TIVA), ondansetron, dexamethasone each reported reduce PONV by approximately 30%. Avoiding or reducing perioperative narcotic analgesics, use an 80% oxygen concentration, proper fluid administration also PONV. The antiemetic have been studied separately. study aimed test efficacy these collectively with without ondansetron in preventing among cholecystectomy. For this study, 160 cholycestectomy (33 males 147 females) were randomized into one three groups. Group O received 4 mg ondansetron; group D 8 mg dexamethasone; P normal saline immediately after induction anesthesia. All propofol-based TIVA, 20 ml/kg Hartman’s solution, 1.5 mg/kg tramadol. Opioids, volatile anesthetics not used any patient. Episodes recorded at 0- 4-h 4- 24-h intervals. incidences 32% group, 30% 33% group. There no significant differences groups (p > 0.05). Ondansetron added collective does further decrease incidence cholycestectomy.