A Longitudinal Study of Low-Level Lead Exposure and Impairment of Renal Function

摘要: Objective. —To determine whether low-level lead exposure is associated with impaired renal function. Design. —Retrospective cohort study. Setting and Participants. —Subjects were 459 men randomly selected from the participants of Normative Aging Study who originally recruited healthy veterans in greater Boston area 1961 periodically examined at Department Veterans Affairs Outpatient Clinic every 3 to 5 years. We reconstructed blood concentrations for period between 1979 1994 using samples either archived red cells or fresh whole blood. Main Outcome Measures. —Serum creatinine concentration. Results. —After adjustment age, body mass index, smoking, alcohol consumption, educational level, hypertension, concentration was positively significantly concurrent serum ( P =.005). A 10-fold increase level predicted an 7 μmol/L (0.08 mg/dL) concentration, which roughly equivalent by 20 years aging. The association also significant among subjects whose had never exceeded 0.48 (10 μg/dL) throughout study period. age-related earlier faster group highest-quartile levels long-term than lowest-quartile levels. Conclusions. —Low-level may impair function middle-aged older men. Longitudinal data suggest acceleration impairment exposure. JAMA . 1996;275:1177-1181)