Separation of Y-chromosomal haplotypes from male DNA mixtures via multiplex haplotype-specific extraction.

作者: Jessica Rothe , Marion Nagy

DOI: 10.1016/J.FSIGEN.2015.07.004

关键词:

摘要: In forensic analysis, the interpretation of DNA mixtures is subject ongoing debate and requires expertise knowledge. Haplotype-specific extraction (HSE) an alternative method that enables separation large chromosome fragments or haplotypes by using magnetic beads in conjunction with allele-specific probes. HSE thus allows physical components a mixture. Here, we present first multiplex Y-chromosomal haplotype consisting six Yfiler short tandem repeat markers from mixture male DNA.

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