Expression of HPV L1 capsid protein in cervical specimens with HPV infection.
作者： Heejeong Lee , Kyung-Ji Lee , Chan-Kwon Jung , Jae-Hwa Hong , Youn-Soo Lee
DOI: 10.1002/DC.20922
关键词:
摘要: We tried to investigate the expression rate of human papillomavirus (HPV) L1 capsid protein in uterine cervical specimens and correlate it with grade dysplasia, HPV genotype age patients. Among proved have by DNA genotyping test, eighty cytology-biopsy matched cases 22 unmatched cytology were selected. Immunostaining for was performed on both smears tissue sections. The expressed mainly nuclei, but occasionally cytoplasm cells located superficial layer squamous epithelium. immunostaining showed positive reaction 47 (46.1%) 10 (12.5%) sections (P = 0.001). Cytologic diagnosis revealed a higher LSILs (25/33; 75.8%) than HSILs cancers (8/20; 40.0% 2/5; 40%, respectively) 0.006). In LSILs, low-risk type those high-risk (88.9% vs. 70.8%). decreased over-40-year-old group compared younger (49.2% 50.8%). Cytology superior detection expression. group, which suggests that might be related favorable disease biology.
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