The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs.

摘要: 30 to 40% of Hartley strain guinea pigs have previously been demonstrated possess a dominant autosomal gene which enables them recognize the antigenicity hapten-poly-L-lysine conjugates as expressed by development both antihapten antibodies and delayed hypersensitivity immunizing antigen. In present study, it was shown that PLL alone weakly antigenic in such genetic responder animals. Immunization with DNP-PLL electrostatically combined foreign albumins elicits production anti-DNP all pigs, although percentage animals demonstrating response therefore considered responders remains 40%. nonantigenic polyanions does not produce an effect. Some degree specificity purified produced nonresponder immunization means fluorescence quenching.