Aerobic activated sludge transformation of vincristine and identification of the transformation products
作者： Tina Kosjek , Noelia Negreira , Ester Heath , Miren López de Alda , Damià Barceló
DOI: 10.1016/J.SCITOTENV.2017.08.061
关键词:
摘要: This study aims to identify (bio) transformation products of vincristine, a plant alkaloid chemotherapy drug. A batch biotransformation experiment was set-up using activated sludge at two concentration levels with and without the addition of a carbon source. Sample analysis was performed on an ultra-high performance liquid chromatograph coupled to a high-resolution hybrid quadrupole-Orbitrap tandem mass spectrometer. To identify molecular ions of vincristine transformation products and to propose molecular and chemical …
harvard.edu
sci-hub.se 参考文章(34)
Tina Kosjek, Noelia Negreira, Miren López de Alda, Damià Barceló, Aerobic activated sludge transformation of methotrexate: identification of biotransformation products. Chemosphere. ,vol. 119, ,(2015) , 10.1016/J.CHEMOSPHERE.2014.04.081
Adi Setyo Purnomo, Toshio Mori, Surya Rosa Putra, Ryuichiro Kondo, Biotransformation of heptachlor and heptachlor epoxide by white-rot fungus Pleurotus ostreatus International Biodeterioration & Biodegradation. ,vol. 82, pp. 40- 44 ,(2013) , 10.1016/J.IBIOD.2013.02.013
Noelia Negreira, Miren López de Alda, Damià Barceló, Degradation of the cytostatic etoposide in chlorinated water by liquid chromatography coupled to quadrupole-Orbitrap mass spectrometry: Identification and quantification of by-products in real water samples Science of The Total Environment. ,vol. 506, pp. 36- 45 ,(2015) , 10.1016/J.SCITOTENV.2014.10.097
Erica Donner, Tina Kosjek, Signe Qualmann, Kresten Ole Kusk, Ester Heath, D. Michael Revitt, Anna Ledin, Henrik Rasmus Andersen, Ecotoxicity of carbamazepine and its UV photolysis transformation products Science of The Total Environment. ,vol. 443, pp. 870- 876 ,(2013) , 10.1016/J.SCITOTENV.2012.11.059
Tina Kosjek, Ester Heath, Boris Kompare, Removal of pharmaceutical residues in a pilot wastewater treatment plant Analytical and Bioanalytical Chemistry. ,vol. 387, pp. 1379- 1387 ,(2007) , 10.1007/S00216-006-0969-1
Tomáš Pluskal, Sandra Castillo, Alejandro Villar-Briones, Matej Orešič, MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data BMC Bioinformatics. ,vol. 11, pp. 395- 395 ,(2010) , 10.1186/1471-2105-11-395
Mojca Zupanc, Tina Kosjek, Martin Petkovšek, Matevž Dular, Boris Kompare, Brane Širok, Željko Blažeka, Ester Heath, Removal of pharmaceuticals from wastewater by biological processes, hydrodynamic cavitation and UV treatment. Ultrasonics Sonochemistry. ,vol. 20, pp. 1104- 1112 ,(2013) , 10.1016/J.ULTSONCH.2012.12.003
Sung Ho Ahn, Michael W. Duffel, John P. N. Rosazza, Oxidations of Vincristine Catalyzed by Peroxidase and Ceruloplasmin Journal of Natural Products. ,vol. 60, pp. 1125- 1129 ,(1997) , 10.1021/NP970226O
Tina Kosjek, Ester Heath, Occurrence, fate and determination of cytostatic pharmaceuticals in the environment Trends in Analytical Chemistry. ,vol. 30, pp. 1065- 1087 ,(2011) , 10.1016/J.TRAC.2011.04.007
Tina Kosjek, Silva Perko, Dušan Žigon, Ester Heath, Fluorouracil in the environment: analysis, occurrence, degradation and transformation. Journal of Chromatography A. ,vol. 1290, pp. 62- 72 ,(2013) , 10.1016/J.CHROMA.2013.03.046