Effect of Oncogenes on Cell Differentiation

摘要: The processes of cell transformation in tissue culture and neoplastic vivo produce cells which are recognizable by their distinctive morphology ability to proliferate under conditions do not support, or severely limit, the proliferation normal counterparts. altered is recognized pathologist tumor biopsies used only for diagnosis malignancy but also staging prognostic prediction. In as foci morphologically distinct from parental-type surround focus. This has been development assays oncogenic viruses (Temin Rubin 1958) identification oncogenes derived tumors introduced into indicator DNA transfection (Shih et al. 1979; Cooper 1982). both cases may be aided excess these relation an indication changes synthesis products allow us distinguish types. Typically, required survival, although “house-keeping” quantitatively altered. They reveal alterations cell-type specific developmentally regulated products. Thus, morphological indicators affecting differentiation cell. idea strengthened analysis differentiated using biochemical molecular biological techniques.