Application of the Nanocrystalline Silver in Treatment of Burn Wounds in Children

摘要: Infection is one of the most frequent and major complications in patients with burn injuries main cause for prolonged in-hospital stay death cases wide-spread burns despite marked progress development treatments methods these patients. Burn infections get complicated by multi-resistant organisms. The colonization infection wounds are a dual clinical problem. On hand, slowing healing process possible based on damaged immune system inadequate perfusion to wound. other infected wound may be potential source spreading antibiotic-resistant microorganisms. pain discomfort patients, as well life-threatening septic conditions. Thus, treatment cost medical care increase, respectively. topical an integral part general burns. agents should posses some important characteristics such broad spectrum antibacterial activity, low resistance level, decreased vapour loss, dehydration prevention, limited adverse effects, control, ease use toxic risk. Due wide variety suitable agents, choice agent depends assessment considerations dressing level its antiseptic effect, influence bioactive abilities epithelization management infection. perfect children provide optimal protection, reparation minimization sequelae. Over last 30 years, knowledge mechanism has made incredible result intensive technological research. new technologies have focused products releasing slowly steadily, which allows lower more efficient concentration. widespread containing silver long history usage activity (Klasen, 2000; Landsdown, 2006; Fong & Wood, 2006). Silver dressings commonly frequently used treatment. contain concentration creates free (or limited) side effect. nitrate solution not applied any due change ionic balance penetration depth. sulphadiazine SSD (Flammazine, Dermazin, Silvadene, Silverdin®, etc.) powerful effect against Gram-positive Gram-negative bacteria, especially MRSA