Control of protein synthesis and mRNA degradation by microRNAs.

摘要: MicroRNAs represent a large family of non-coding small RNAs that function as the major endogenous triggers for RNA interference. Hundreds microRNAs have been identified through cloning, bioinformatic predictions, and high-throughput pyrosequencing. They are believed to suppress gene expression post-transcriptional regulation via either translational repression or mRNA turnover. Over one third human genes predicted targets microRNAs. However, even after extensive studies, precise mechanism by which they remain elusive. Although controversy remains, recent advances shined new light on how regulate their targets. A better understanding should facilitate studies function.