Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang

摘要: Most normal diploid human cells do not express telomerase activity and are unable to maintain telomere length with ongoing cell divisions. We show that the of single-stranded G-rich telomeric 3′-overhang is proportional rate shortening in four types exhibit different rates culture. These results provide direct evidence size overhang fixed but subject regulation. The potential ability manipulate this has profound implications both for slowing replicative aging accelerating loss cancer combination anti-telomerase therapies.