Determination of EGFR Status in Gliomas
作者： Angélique Guillaudeau , Karine Durand , Isabelle Pommepuy , Sandrine Robert , Alain Chaunavel
DOI: 10.1097/PAI.0B013E31818DB320
关键词:
摘要: Epidermal growth factor receptor (EGFR) is produced during the molecular pathogenesis of glioma, and new anti-EGFR molecules are available for therapeutics. Consequently, analyses EGFR gene protein frequently used glioma characterization. We compare accuracy usefulness 2 currently techniques histologic classification gliomas. Fluorescent in situ hybridization (FISH) immunohistochemistry (IHC) were to assess amplification abundance a series 35 gliomas, including World Health Organization (WHO) grade I, II, III astrocytomas (AI, AII, AIII), II tumors with oligodendroglial component (OII, OIII) IV glioblastomas (GBs). was found one-third studied. It frequent GB OIII but never AI, AIII, OII tumors. IHC FISH provided similar findings tumor, despite fact that, contrast amplification, overexpressed AIII GB. observed not containing protein: therefore unnecessary when shows no expression. seems be restricted high-grade tumors, WHO astrocytomas,
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