Interaction of arsenic trioxide As2O3 with DNA and RNA.
作者： Shohreh Nafisi , Amir Sobhanmanesh , Kamran Alimoghaddam , Ardeshir Ghavamzadeh , Heidar-Ali Tajmir- Riahi
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摘要: Arsenic salts have been used for centuries to treat a variety of medical conditions ranging from infectious disease cancer. More recently, trivalent arsenic trioxide was found exhibit high antitumor activity towards hematological malignancies. Even though much is known about and DNA damage by As2O3, there has no report on the interaction with isolated or RNA. Therefore, it interest examine As2O3 RNA in aqueous solution at physiological pH. FTIR UV-visible difference spectroscopic methods were characterize nature drug–DNA drug–RNA interactions determine As binding site, constant, sequence selectivity, helix stability, biopolymer secondary structure As2O3–polynucleotide complexes vitro. The studies conducted (phosphate) ratios 1/40, 1/20, 1/10, 1/5, final (P) conce...
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