DNA−Chlorophyllin Interaction
作者： Jean-F Neault , HA Tajmir-Riahi , None
DOI: 10.1021/JP972082S
关键词: Pigment 、 Chemistry 、 Fourier transform infrared spectroscopy 、 Phosphate 、 Aqueous solution 、 Metal 、 Binding constant 、 DNA 、 Nuclear chemistry 、 Chlorophyllin
摘要: Porphyrins and their metal derivatives are strong DNA binders with association constants of around 106 M-1. Some these compounds have been used for radiation sensitization therapy cancer targeted to interact cellular DNA. Chlorophyllin (CHLN), a food-grade derivative chlorophyll (CHL), the ubiquitous green plant pigment widely consumed by humans, is potent inhibitor experimental carcinogenesis. The aim this study was examine interaction calf-thymus chlorophyllin in aqueous solution at physiological pH, CHLN/DNA(phosphate) molar ratios (r) 1/80, 1/40, 1/20, 1/10 1/4, 1/2. Fourier transform infrared (FTIR) difference spectroscopy determine CHLN binding mode, constant, sequence selectivity, secondary structure, structural variations DNA−CHLN complexes solution. Spectroscopic evidence showed that low concentration (r = 1/80), binds via intercalative mode into G−C A−T-rich ...
acs.org
sci-hub.se 参考文章(24)
Thomas G. Spiro, Biological applications of Raman spectroscopy Wiley. ,(1987)
Lennart Romert, Margareta Curvall, Dag Jenssen, Chlorophyllin is both a positive and negative modifier of mutagenicity. Mutagenesis. ,vol. 7, pp. 349- 355 ,(1992) , 10.1093/MUTAGE/7.5.349
Joseph D. Puglisi, Jacqueline R. Wyatt, Ignacio Tinoco, Solution conformation of an RNA hairpin loop Biochemistry. ,vol. 29, pp. 4215- 4226 ,(1990) , 10.1021/BI00469A026
Gary D. Strahan, Dongsheng Lu, Masamichi Tsuboi, Kazuo Nakamoto, Resonance raman spectra of electronically excited, water-soluble copper(II) porphyrins bound to oligonucleotides : possibility of translocation from a GC to an AT site The Journal of Physical Chemistry. ,vol. 96, pp. 6450- 6457 ,(1992) , 10.1021/J100194A064
E. B. Starikov, M. A. Semenov, V. Ya. Maleev, A. I. Gasan, Evidential study of correlated events in biochemistry: Physicochemical mechanisms of nucleic acid hydration as revealed by factor analysis Biopolymers. ,vol. 31, pp. 255- 273 ,(1991) , 10.1002/BIP.360310302
S. Arimoto, T. Negishi, H. Hayatsu, Inhibitory effect of hemin on the mutagenic activities of carcinogens Cancer Letters. ,vol. 11, pp. 29- 33 ,(1980) , 10.1016/0304-3835(80)90125-1
Leigh Ann Lipscomb, Fang Xiao Zhou, Steven R. Presnell, Rebecca J. Woo, Mary E. Peek, R. Richard Plaskon, Loren Dean Williams, Structure of a DNA−Porphyrin Complex† Biochemistry. ,vol. 35, pp. 2818- 2823 ,(1996) , 10.1021/BI952443Z
S. Brahms, J. Brahms, J. Pilet, Infrared Studies on the Backbone Conformation of Nucleic Acids Israel Journal of Chemistry. ,vol. 12, pp. 153- 163 ,(1974) , 10.1002/IJCH.197400015
D. M. Loprete, K. A. Hartman, Conditions for the stability of the B, C, and Z structural forms of poly(dG-dC) in the presence of lithium, potassium, magnesium, calcium, and zinc cations. Biochemistry. ,vol. 32, pp. 4077- 4082 ,(1993) , 10.1021/BI00066A032
Jean-François Neault, Heidar-Ali Tajmir-Riahi, RNA-Diethylstilbestrol Interaction Studied by Fourier Transform Infrared Difference Spectroscopy Journal of Biological Chemistry. ,vol. 272, pp. 8901- 8904 ,(1997) , 10.1074/JBC.272.14.8901