Metabolic Site and Time Course of Cortisol Action on Glucose Uptake, Lactic Acid Output, and Glucose 6-Phosphate Levels of Rat Thymus Cells in Vitro

作者: A Munck

DOI: 10.1016/S0021-9258(18)93619-7

关键词:

摘要: Abstract In rat thymus cells exposed under aerobic conditions to a glucose pulse, cortisol at 10-6 m reduces the rates of uptake and lactic acid output, magnitude glucose-induced increase in 6-phosphate. Effects are discernible by 15 20 min exposure cortisol. These results interpreted as showing that produces block level transport or phosphorylation, both. Under anaerobic marked Pasteur effect is observed, all above effects abolished.

参考文章(14)
William S. Bullough, Hormones and Mitotic Activity Vitamins and Hormones Series. ,vol. 13, pp. 261- 292 ,(1955) , 10.1016/S0083-6729(08)61028-6
Maynard H. Makman, B. Dvorkin, Abraham White, Alterations in Protein and Nucleic Acid Metabolism of Thymocytes Produced by Adrenal Steroids in Vitro Journal of Biological Chemistry. ,vol. 241, pp. 1646- 1648 ,(1966) , 10.1016/S0021-9258(18)96761-X
Hans Ulrich Bergmeyer, Methods of Enzymatic Analysis ,(1963)
D. R. Drury, Control of Blood Sugar The Journal of Clinical Endocrinology & Metabolism. ,vol. 2, pp. 421- 430 ,(1942) , 10.1210/JCEM-2-7-421
B. G. Overell, S. E. Condon, V. Petrow, The effect of hormones and their analogues upon the uptake of glucose by mouse skin in vitro. Journal of Pharmacy and Pharmacology. ,vol. 12, pp. 150- 153 ,(2011) , 10.1111/J.2042-7158.1960.TB12646.X
DONALD BARTLETT, YOSHIKO MORITA, ALLAN MUNCK, Rapid Inhibition by Cortisol of Incorporation of Glucose in vivo into the Thymus of the Rat Nature. ,vol. 196, pp. 897- 898 ,(1962) , 10.1038/196897A0