Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients

摘要: BACKGROUND Chemoresistance and metastasis are the main reasons for failure of current treatments with sarcoma patients. Novel biomarkers required to predict response treatment. The oncogene MTDH/AEG1 long noncoding RNA (lincRNA) HOTAIR two novel factors involved in drug resistance various types solid tumors. However, correlation between MTDH/AEG-1 expression is unknown. METHODS Expression MTDH protein or was detected by Western blotting qRT-PCR, respectively, primary metastatic patient tissue samples. RESULTS High individual co-expression observed three four six eight tumor level both correlated a likelihood metastasize. lower samples pre-treated irradiation and/or chemotherapy as compared those that had not been treated. seemed correlate percent necrosis seen different CONCLUSIONS levels high probability metastasis. By contrast, reduced good treatment terms necrosis, suggesting potential efficacy. Whether we can disease progression remains be seen. Additional study needed better define best clinical application outcome.