Interfering peptides targeting protein-protein interactions: the next generation of drugs?
作者： Heriberto Bruzzoni-Giovanelli , Valerie Alezra , Nicolas Wolff , Chang-Zhi Dong , Pierre Tuffery
DOI: 10.1016/J.DRUDIS.2017.10.016
关键词:
摘要: Protein-protein interactions (PPIs) are well recognized as promising therapeutic targets. Consequently, interfering peptides (IPs) - natural or synthetic capable of with PPIs receiving increasing attention. Given their physicochemical characteristics, IPs seem better suited than small molecules to interfere the large surfaces implicated in PPIs. Progress on peptide administration, stability, biodelivery and safety also encouraging interest drug development. The concept has been validated for several PPIs, generating great expectations potential. Here, we describe approaches methods useful identification silico, biological-based strategies design optimization. Selected in-vivo-validated examples described advantages, limitations potential tools discussed.
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