Up-regulation of gelatinases in the colorectal adenoma-carcinoma sequence
作者： Antonio Z. Gimeno-García , Alfredo Santana-Rodríguez , Alejandro Jiménez , Adolfo Parra-Blanco , David Nicolás-Pérez
DOI: 10.1016/J.EJCA.2006.06.025
关键词:
摘要: Gelatinase activity has been associated with colorectal cancer (CRC) invasion and metastasis. However, it remains unresolved whether these proteases participate in early carcinogenesis. The of metalloproteinases (MMP) 2 9 were measured by zymography 122 adenomas, 22 CRC samples, 12 hyperplasic polyps 114 matched normal mucosal samples from patients undergoing colonoscopy. There was a progressive significant increase pro-MMP-9 adenoma to tissue, whereas the latent active forms MMP-2 exclusively up-regulated samples. Among neoplastic polyps, significantly higher advanced versus non-advanced adenomas those harbouring high grade dysplasia. In addition, positive correlation observed between MMP-9 size adenomas. present study demonstrates that is markedly adenomatous tissue suggests this gelatinase might be marker for
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