Metallothionein Isoform 3 Overexpression Is Associated with Breast Cancers Having a Poor Prognosis

摘要: The third isoform (MT-3) of the metallothionein gene family is unique in that it has a limited tissue distribution, not induced by metals, neuronal growth inhibitory activity, and sequesters zinc more effectively under zinc-depleted conditions. goal present study was to determine whether MT-3 absent normal breast tissue, overexpressed cancers, if overexpression would be associated with disease outcome. A combination immunohistochemistry reverse-transcription polymerase chain reaction used demonstrate had no detectable expression mRNA or protein. Using immunohistochemistry, shown 25 34 cases cancer. In all positive staining, diffusely localized cytoplasm. tumors from these were divided as outcome based on known 5-year survival, 20 patients being free at 5 years (good outcome) other 14 having recurring within (bad outcome). When analyzed for there trend increased immunoreactivity group bad outcomes. However, when tumor subgrouping further defined basis carcinoma situ (CIS), marked significant difference staining between good Limited DCIS, significantly outcomes compared those Thus, studies selected cancers poor prognosis.