Neu (c-erbB-2), a tumor marker in carcinoma of the female breast.

摘要: The c-erbB-2 oncogene encodes a transmembrane phosphoglycoprotein. This molecule appears to be growth factor receptor in the family of tyrosine kinase receptors; however, its ligand has not yet been identified. Amplification and/or overexpression breast adenocarcinomas occurs frequently and occurrence implies more advanced malignancy. functional tumor marker is readily identified by appropriate DNA antibody probes. large external domain gene product promising target for immunodiagnostic immunotherapeutic modalities.