Purine nucleosides in neuroregeneration and neuroprotection.
作者： Filipa F Ribeiro , Sara Xapelli , Catarina Miranda-Lourenco , Sara R Tanqueiro , Joao Fonseca-Gomes
DOI: 10.1016/J.NEUROPHARM.2015.11.006
关键词:
摘要: In the present review, we stress importance of purine nucleosides, adenosine and guanosine, in protecting nervous system, both centrally peripherally, via activation their receptors intracellular signalling mechanisms. A most novel part review focus on mechanisms neuronal regeneration that are targeted by including a recently identified action axonal growth microtubule dynamics. Discussion role nucleosides transversally with established neurotrophic factors, e.g. brain derived factor (BDNF), glial (GDNF), is also focused considering intimate relationship between some receptors, as case A2A for neurotrophins. This article Special Issue entitled 'Purines Neurodegeneration Neuroregeneration'.
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