Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons
作者： F. Reverter , T. Prodromakis , Y. Liu , P. Georgiou , K. Nikolic
DOI: 10.1109/ISCAS.2014.6865214
关键词:
摘要: This paper identifies and addresses key design considerations trade-offs in the implementation of a CMOS high-resolution microheater array for Lab-on-Chip (LOC) applications. Specifically, this is investigated context facilitating vitro thermal stimulation single neurons. The analyses electro-thermal response (by means COMSOL simulations) reliability issues (such as melting electromigration) different designs. analysis shows that small-area heater more efficient terms power, but it has problems essentially due to electromigration effects. For proposed designs, expected lifetime few days (in continuous operation) worst scenario, which still generally acceptable LOC
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