Recessive mutations conferring resistance to carbon catabolite repression of galactokinase synthesis in Saccharomyces cerevisiae.

摘要: A total of 37 recessive mutations showing enhanced resistance to the glucose repression galactokinase synthesis have been isolated by a selection procedure with GAL81 gal7 double mutant. These were grouped into three different complementation classes. One class, reg1, contains mutants arising from at site close to, but complementing, gal3 locus. The reg1 mutant also showed invertase not that alpha-D-glucosidase. two other classes identified as GAL82 locus and GAL83 locus, respectively, which various dominant previously. When in constitutive background due or gal80 mutation, did show mutually additive effect on synthesis, while (or GAL83) did. Based upon specific behavior cells genotypes for above genes response concentration galactose medium, we propose model involving independent circuits signals regulation structural pathway enzymes.